期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 10, 期 1, 页码 15-22出版社
WESTMINSTER PUBL INC
DOI: 10.1177/106689690201000104
关键词
thyroid; Hashimito's thyroiditis; papillary carcinoma; RET gene; RET/PTC rearrangement
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR008084] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01 RR 08084] Funding Source: Medline
The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thyroid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients with high frequency. We tested the prevalence of RET/PTC rearrangements in 26 HT, in 6 papillary carcinomas arising in the back-round of HT, and in 27 papillary carcinomas not associated with HT. We detected no RET/PTC rearrangements in HT or papillary carcinomas arising in the background of HT, in contrast to a 33% prevalence among papillary carcinomas not associated with HT. However, the expression of wild-type RET was found in more than half of papillary carcinomas. These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement.
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