期刊
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
卷 80, 期 5, 页码 517-523出版社
NATL RESEARCH COUNCIL CANADA
DOI: 10.1139/O02-145
关键词
beta-barrels; eyelet region; porins; E. coli; alpha-haemolysin
OmpF and PhoE from Escherichia coli and related homologous proteins from other Gram-negative bacteria allow the passive transport of small polar molecules across the bacterial outer membrane. In vitro, they exhibit voltage gating depending on the experimental conditions. We review current hypotheses on the underlying molecular mechanism of voltage gating of OmpF porin and show how computer simulations can be used to examine each of the proposed mechanisms.
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