期刊
JOURNAL OF PROTEOME RESEARCH
卷 1, 期 1, 页码 21-26出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr015504q
关键词
proteomics; protein identification; SEQUEST; data analysis; software; differential analysis; subtractive analysis; MudPIT; assembly
资金
- NCI NIH HHS [R33CA81665, R33 CA081665-04] Funding Source: Medline
- NCRR NIH HHS [RR11823, P41 RR011823-04, P41 RR011823] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R33CA081665] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR011823] Funding Source: NIH RePORTER
The components of complex peptide mixtures can be separated by liquid chromatography, fragmented by tandem mass spectrometry, and identified by the SEQUEST algorithm. Inferring a mixture's source proteins requires that the identified peptides be reassociated. This process becomes more challenging as the number of peptides increases. DTASelect, a new software package, assembles SEQUEST identifications and highlights the most significant matches. The accompanying Contrast tool compares DTASelect results from multiple experiments. The two programs improve the speed and precision of proteomic data analysis.
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