期刊
ARTHRITIS RESEARCH
卷 4, 期 3, 页码 157-164出版社
BMC
DOI: 10.1186/ar401
关键词
arthritis; matrix metalloproteinases; mitogen-activated protein kinases; nuclear factor kappa B; transcription
类别
资金
- NCI NIH HHS [CA-77267, R01 CA077267] Funding Source: Medline
- NIAMS NIH HHS [R37 AR026599, R01 AR026599, AR-46977, AR-26599, AR-02024, R01 AR046977] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA077267] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R37AR026599, K01AR002024, R01AR046977, R01AR026599] Funding Source: NIH RePORTER
Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-alpha, and elevated levels of these collagenases are observed in arthritic tissues. Therefore, cytokine-mediated MMP-1 and MMP-13 gene regulation is an important issue in arthritis research. In this review, we discuss current models of MMP-1 and MMP-13 transcriptional regulation, with a focus on signaling intermediates and transcription factors that may be future targets for the development of new arthritis drugs.
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