期刊
BREAST CANCER RESEARCH
卷 4, 期 3, 页码 109-121出版社
BMC
DOI: 10.1186/bcr428
关键词
breast cancer; CCAAT/enhancer binding proteins; dominant-negative transcription factor; mammary development; translational regulation
类别
资金
- NATIONAL CANCER INSTITUTE [P50CA088843] Funding Source: NIH RePORTER
- NCI NIH HHS [P50 CA88843, P50 CA088843] Funding Source: Medline
- NCPDCID CDC HHS [NCI P30] Funding Source: Medline
CCAAT/enhancer binding proteins (C/EBPs) are a family of leucine zipper, transcription factors that bind to DNA as homodimers and heterodimers. They regulate cellular proliferation, differentiation and apoptosis in the mammary gland. Multiple protein isoforms, including truncated, dominant negatives, are generated by translation of the C/EBP transcript or via proteolytic cleavage of the full-length C/EBP protein. Gene deletion of individual C/EBP family members has demonstrated an essential role for C/EBP in normal mammary development, while transgenic and overexpression studies provide evidence that the dominant-negative C/EBP-liver-enriched inhibitory protein isoform induces proliferation in mammary epithelial cells. Mounting evidence suggests that alterations in the ratio of the C/EBPbeta-liver-enriched inhibitory protein isoform and the C/EBPbeta-liver-enriched activating protein isoform may play a role in the development of breast cancer. This review will consequently focus on C/EBP actions in normal mammary development and on the emerging data that supports a role in breast cancer.
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