期刊
CEPHALALGIA
卷 35, 期 1, 页码 73-78出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102414534082
关键词
Occipital nerve stimulation; migraine; primary headache disorders; paresthesia; randomized trial
资金
- SJM
- Spinal Modulation Inc
Introduction: Occipital nerve stimulation (ONS) may provide pain relief in migraine patients. In this double-blinded trial we investigated the significance of paresthesia and possible placebo effects. Methods: Patients already treated with ONS reporting stable treatment effect were included. Effective stimulation,'' subthreshold stimulation'' and no stimulation'' were compared. Patients cycled through all three treatment groups. Outcome was measured using the visual analog scale (VAS) for pain, McGill Pain Questionnaire and SF-36. Results: Eight patients were included, mean preoperative VAS was 8.20 +/- 1.22. A significant improvement in pain was observed in favor of suprathreshold stimulation compared to subthreshold stimulation (1.98 +/- 1.56 vs 5.65 +/- 2.11). Pain also significantly improved under subthreshold stimulation compared to no stimulation (5.65 +/- 2.11 vs 8.45 +/- 0.99). No changes in SF-36 were observed. Conclusions: Paresthesia is not required to achieve pain reduction but suprathreshold stimulation yields better results, underlining the significance of stimulation parameter customization.
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