期刊
CEPHALALGIA
卷 33, 期 3, 页码 182-189出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102412469738
关键词
Cluster headache; depression; incidence; migraine; risk; Taiwan
资金
- Taiwan National Science Council [98-2314-B-010-019-MY2, NSC 100-2628-E-010-002-MY3]
- Taipei Veterans General Hospital [VGHUST101-G7-1-1, V101C-106, V101E7-003]
- NSC support for Centre for Dynamical Biomarkers and Translational Medicine
- National Central University, Taiwan [NSC100-2911-I-008-001]
- Brain Research Center, National Yang-Ming University
- Tri-Service General Hospital [TSGH-C101-159]
- Ministry of Education, Aim for the Top University Plan
Objective: To investigate whether cluster headache (CH) was a risk factor for depression in a nationwide population-based follow-up study. Background: There are few studies about the relationship between CH and depression, and prior research has been limited by cross-sectional studies or small sample sizes. Methods: We identified 673 CH patients from the Taiwan National Health Insurance database between 2005 and 2009. The two comparison cohorts included age-, sex- and Charlson's score-matched migraine patients (n = 2692) and controls (patients free from migraine or CH, n 2692). The cumulative incidence of depression was compared among these three cohorts until the end of 2009. We also calculated predictors of depression in the CH cohort. Results: After the median 2.5-year follow-up duration, the CH cohort had a greater risk for developing depression compared to the control cohort (adjusted hazard ratio; aHR = 5.6, 95% CI 3.0-10.6, p < 0.001) but not the migraine cohort (aHR = 1.1, 95% CI 0.7-1.7, p = 0.77). Of the CH patients, the number of cluster bout periods per year was a risk factor for depression (aHR = 3.8, 95% CI 2.6-5.4, p < 0.001). Conclusion: Our results showed that CH is associated with an increased risk for depression. The strength of this association is similar to that of migraine.
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