期刊
CEPHALALGIA
卷 31, 期 14, 页码 1452-1458出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102411421025
关键词
Migraine; morphometry; cortical thickness; brain structure
资金
- National Institute of Neurological Disorders and Stroke [NS061572, NS058386, NS045839, RR002305]
Objective: Previous studies have reported gray matter alterations in patients with migraine, particularly thinning of the cingulate gyrus, and thickening of the somatosensory cortex (SSC) and visual motion processing areas (V3A/MT+). We attempted to replicate these findings in a larger patient population. Methods: Brain anatomy was collected with 3T MRI. Surface-based morphometry was used to segment each brain volume, reconstruct and inflate the cortical sheet, and estimate gray matter thickness. Results: Eighty-four age and sex-matched participants (28 migraine with aura, 28 migraine without aura, and 28 controls) were studied. No significant differences in somatosensory, cingulate gyrus, or V3A/MT+ cortical thickness were found between the groups, including analysis of specific subregions previously reported to be affected. Whole brain analysis found no regions of differential gray matter thickness between groups. A highly significant inverse correlation between age and whole brain and regional cortical thickness was identified. Power analyses indicate that even a small difference (similar to 0.07 to 0.14 mm) in cortical thickness could have been detected between groups given the sample size. Interpretation: Using highly sensitive surface-based morphometry, no differences in cortical thickness between patients with migraine and controls could be identified.
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