期刊
SCIENCE
卷 295, 期 5560, 页码 1722-1726出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.295.5560.1722
关键词
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Type III secreted effector proteins of bacterial, pathogens play central roles in virulence, yet are notoriously difficult to identify. We used an in vivo genetic screen to identify 13 effectors secreted by the type III apparatus (called Hrp, for hypersensitive response and pathogenicity) of the plant pathogen Pseudomonas syringae. Although sharing little overall homology, the amino-terminal regions of these effectors had strikingly similar amino acid compositions. This feature facilitated the bioinformatic prediction of 38 P. syringae effectors, including 15 previously unknown proteins, The secretion of two of these putative effectors was shown to be type III-dependent. Effectors showed high interstrain variation, supporting a rote for some effectors in adaptation to different hosts.
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