期刊
SCIENCE
卷 295, 期 5560, 页码 1669-1678出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1069883
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资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD037105] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P40RR015044, R01RR006591] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061005] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR-15044, RR-06591] Funding Source: Medline
- NICHD NIH HHS [HD-37105] Funding Source: Medline
- NIGMS NIH HHS [GM-61005] Funding Source: Medline
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
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