期刊
CRITICAL CARE MEDICINE
卷 30, 期 3, 页码 497-500出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003246-200203000-00001
关键词
vasopressin; nervous system; shock
Objectives., To assess the mechanisms underlying the inappropriately low plasma vasopressin levels reported in septic shock. Design: Prospective case series. Setting., A 26-bed general medical intensive care unit at a university hospital. Patients: Septic shock patients. Measurements and Main Results., In three consecutive patients with septic shock, plasma vasopressin levels, circulating vasopressinase activity, baroreflex sensitivity, and neurohypophyseal vasopressin content were assessed. Plasma vasopressin concentration was unexpectedly within normal range in two patients (1.6 pg/mL and 1.8 pg/mL) and increased in one (16 pg/mL). In all cases, vasopressinase activity was undetectable, baroreflex sensitivity was decreased, and the high signal intensity of the posterior lobe of the pituitary gland on T1-weighted magnetic resonance images was absent. Magnetic resonance imaging and plasma vasopressin levels normalized after recovery from shock in the patient who survived. Conclusion: These data suggest that in septic shock, inappropriately low plasma levels of vasopressin are at least partly related to a depletion of vasopressin stores in the neurohypophysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据