期刊
NEUROSCIENCE LETTERS
卷 320, 期 1-2, 页码 5-8出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02573-3
关键词
prefrontal cortex; working memory; episodic memory; associative memory; encoding; transcranial magnetic stimulation
Functional neuroimaging suggests asymmetries of memory encoding and retrieval in the prefrontal lobes, but different hypotheses have been presented concerning the nature of prefrontal hemispheric specialization. We studied an associative memory task involving pairs of Kanji (Chinese) pictographs and unfamiliar abstract patterns. Subjects were ten Japanese adults fluent in Kanji, so only the abstract patterns represented novel material. During encoding, transcranial magnetic stimulation (TMS) was applied over the left and right dorsolateral prefrontal cortex (DLPFC). A significant (P < 0.05) reduction in subsequent recall of new associations was seen only with TMS over the right DLPFC. This result suggests that the right DLPFC contributes to encoding of visual-object associations, and is consistent with a material-specific rather than a process-specific model of mnemonic function in DLPFC. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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