期刊
CLINICAL INFECTIOUS DISEASES
卷 34, 期 1, 页码 98-102出版社
UNIV CHICAGO PRESS
DOI: 10.1086/324745
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资金
- NIAID NIH HHS [AI-25897] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI025897] Funding Source: NIH RePORTER
Persons with human immunodeficiency virus (HIV) infection might be at risk for ischemic cardiovascular disease (CVD). We reviewed the records of 16 HIV-infected persons with proven CVD (8 cases of angina and 8 cases of myocardial infarctions). This represents 1.7% of HIV-infected persons seen at our institution from 1 April 1999 through 25 April 2000. In comparison with 32 HIV-infected age- and sex-matched controls, case patients had more risk factors for CVD (median number of risk factors for CVD, 3 versus 1;), lower P < .001 nadir CD4(+) lymphocyte counts (median, 101 cells/mm(3) versus 278 cells/mm(3); P = .02), and a longer duration of prior exposure to nucleoside analogs (median, 190 weeks versus 130 weeks;P = .02). There was no difference in the duration of exposure to protease inhibitors. Ischemic CVD occurs in HIV-infected persons and appears to be most closely associated with traditional risk factors for coronary artery disease (for example, hypertension and hypercholesterolemia). Lower CD4(+) lymphocyte counts and duration of HIV infection might also be risk factors or markers for the development of ischemic CVD.
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