期刊
OSTEOPOROSIS INTERNATIONAL
卷 13, 期 12, 页码 990-995出版社
SPRINGER-VERLAG LONDON LTD
DOI: 10.1007/s001980200137
关键词
birth cohort; lifetime fracture history; life-table analysis; multiple fractures; New Zealand
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH045070] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH-45070] Funding Source: Medline
While much is known regarding the incidence and pattern of fractures during growth, information is sparse as to how many children fracture repeatedly and how many remain fracture-free during growth. The Dunedin Multidisciplinary Health and Development Study, a birth cohort, whose members were questioned regularly throughout growth (at ages 5, 7, 9, 11, 13, 15 and 18 years) concerning injuries including fractures, has provided a unique opportunity to answer these questions. Life-table analysis showed that approximately half the children remained fracture-free throughout growth [girls 60.1%, (95% CI 54.7-65.0) and boys 49.3% (95% CI 44.0-54.4)]. Data on fracture history, for participants seen at every phase, was available for 601 members through to the age of 18 years (61.1% of the cohort seen at age 5 years). Two hundred and ninety-one of these 601 participants reported 498 fractures, with 172 sustaining a single fracture, and 119 more than one fracture (15.8% girls and 23.4% boys). The most common site of fracture was the wrist/forearm (24.1% of all fractures). We conclude that although bone fractures are a common adverse event in childhood, half of all children remain fracture-free throughout growth.
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