期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 92, 期 3, 页码 1232-1238出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00655.2001
关键词
convective ventilatory inhomogeneity; posture; single-breath washout; supine
We studied the effects on aerosol bolus inhalations of small changes in convective inhomogeneity induced by posture change from upright to supine in nine normal subjects. Vital capacity single-breath nitrogen washout tests were used to determine ventilatory inhomogeneity change between postures. Relative to upright, supine phase III slope was increased 33+/-11% (mean +/- SE, P<0.05) and phase IV height increased 25&PLUSMN;11% (P<0.05), consistent with an increase in convective inhomogeneity likely due to increases in flow sequencing. Subjects also performed 0.5-mum-particle bolus inhalations to penetration volumes (V-p) between 150 and 1,200 ml during a standardized inhalation from residual volume to 1 liter above upright functional residual capacity. Mode shift (MS) in supine posture was more mouthward than upright at all V-p, changing by 11.6 ml at V-p = 150 ml (P<0.05) and 38.4 ml at V-p = 1,200 ml (P<0.05). MS and phase III slope changes correlated positively at deeper Vp. Deposition did not change at any V-p, suggesting that deposition did not cause the MS change. We propose that the MS change results from increased sequencing in supine vs. upright posture.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据