期刊
AMERICAN JOURNAL OF ROENTGENOLOGY
卷 178, 期 3, 页码 687-691出版社
AMER ROENTGEN RAY SOC
DOI: 10.2214/ajr.178.3.1780687
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OBJECTIVE. The purpose of our study was to provide new sonographic criteria for fine-needle aspiration biopsy of nonpalpable solid thyroid nodules. MATERIALS AND METHODS. Sonographic scans of 155 nonpalpable thyroid nodules in 132 patients were prospectively classified as having positive or negative findings. Sono-graphic findings that suggested malignancy included microcalcifications, an irregular or microlobulated margin, marked hypoechogenicity, and a shape that was more tall than it was wide. even one of these sonographic features was present, die nodule was classified as positive (malignant). If a nodule had none of the features described, it was classified as negative (benign). final diagnosis of a lesion as benign (n = 106) or malignant (n = 49) was confirmed by fine-aspiration biopsy and follow-up (>6 months) in 83 benign nodules, by fine-needle aspiration biopsy and surgery in 44 malignant and 15 benign lesions, and by surgery alone in five malignant and eight benign lesions. The sensitivity, specificity, positive predictive value, negative value, and accuracy were calculated on the basis of our proposed classification method. RESULTS. Of 82 lesions classified as positive, 46 were malignant. Of 73 lesions classified negative, three were malignant. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy based on our sonographic classification method were 93.8%, 66%, 56.1%, 95.9%, and 74.8%, respectively. CONCLUSION. Considering the high level of sensitivity of our proposed sonographic fine-needle aspiration biopsy should be performed on thyroid nodules classified positive, regardless of palpability.
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