期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 17, 期 -, 页码 17-20出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/17.suppl_2.17
关键词
aluminium; Alzheimer's disease; inflammation; reactive oxygen species
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES007992] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016794] Funding Source: NIH RePORTER
- NIA NIH HHS [AG-16794] Funding Source: Medline
- NIEHS NIH HHS [ES 7992] Funding Source: Medline
Aluminium is a trivalent cation that does not undergo redox changes. It has. nonetheless, been implicated in a variety of neurological disorders that have been associated with an increase in the formation of reactive oxygen species (ROS). The exact mechanism of aluminium toxicity is not known. However, accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, leading to tissue damage. A review of the epidemiological and clinical evidence linking aluminium to Alzheimer's disease (AD) is presented. The article discusses the role of aluminium in two mechanisms that have been linked to neurodegenerative disorders, including AD. Studies are summarized that describe how aluminium can potentiate iron-induced oxidative events, Involvement of aluminium in inflammatory responses, mediated by interleukins and other inflammatory cytokines, is also discussed. Although a direct relationship between aluminium and AD has not been clearly demonstrated, a detailed mechanistic basis for the hypothesis that aluminium may exacerbate events associated with AD is clearly emerging. The results discussed here have broad implications for the role played by aluminium and other metals in neurodegenerative diseases, and suggest that long-term exposure to supra-physiological amounts these metals should be avoided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据