期刊
JOURNAL OF INFECTIOUS DISEASES
卷 185, 期 1, 页码 61-68出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/338123
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [Z01AI000865, ZIAAI000865] Funding Source: NIH RePORTER
Highly active antiretroviral therapy (HAART) initiated during acute human immunodeficiency virus (HIV) infection may preserve HIV-specific CD4(+) T cell responses that are thought to enhance HIV-specific CD8(+) T cell function. The present pilot study was designed to determine whether preserved HIV-specific immune responses are augmented by the administration of the immunomodulatory agent interleukin (IL)-2. Nine persons recently (<6 months) infected with HIV were randomized to receive HAART alone or HAART plus 3 cycles of intermittent IL-2 during a 12-month period. Although HAART plus IL-2 significantly increased counts of total and naive CD4(+) T cells, compared with HAART alone, there was no increase in CD4(+) or CD8(+) HIV-specific immune responses. In addition, adjuvant IL-2 therapy did not reduce the pool of HIV-infected resting CD4(+) T cells. Thus, although intermittent IL-2 plus HAART quantitatively increased CD4(+) T cells, this increase was not selective for HIV-specific CD4(+) or CD8(+) T cell responses in recently infected persons.
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