期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 17, 期 -, 页码 23-27出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/17.suppl_11.23
关键词
atherosclerosis; diabetes; dyslipidaemia; inflammation; oxidative stress; uraemia
Hyperglycaemia induces mitochondrial superoxide production, increases oxidative stress, and leads to activation of the acute-phase response. Hyperglycaemia, impaired renal function, and uraemia cause inflammatory and oxidative processes. Advanced oxidation protein products and advanced glycation end products are formed, leading to subsequent cytokine release. This promotes alterations in lipoprotein metabolism, composition, and function. These changes result in a highly atherogenic environment, perpetuating the vicious cycle of accelerated atherogenesis. The terminal pathway is an elevation of C-reactive protein, a biomarker of both overall and cardiovascular outcome.
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