期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 17, 期 -, 页码 23-24出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/17.suppl_9.23
关键词
dystroglycan; podocyte
alpha- and beta-dystroglycan were detected at the base of foot processes of human glomeruli by immunoelectron microscopy. Perfusion of isolated rat kidneys with the polycationic compound protamine sulfate was found to induce rapid (i.e. within 15 min) flattening of foot processes in an energy- and actin-dependent fashion. Here we provide evidence that (i) glomeruli possess large amounts of a specifically composed complex; (ii) this complex may undergo changes in human glomerular disease; and (iii) flattening of foot processes is directly associated with dissociation of laminin-dystroglycan complexes.
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