Lung function during and after prolonged head-down bed rest

We determined the effects of prolonged head-down tilt bed rest (HDT) on lung mechanics and gas exchange. Six subjects were studied in supine and upright postures before (control), during [day 113 (D113)], and after (R + number of days of recovery) 120 days of HDT. Peak expiratory flow (PF) never differed between positions at any time and never differed from controls. Maximal midexpiratory flow (FEF25-75%) was lower in the supine than in the upright posture before HDT and was reduced in the supine posture by about 20% between baseline and D113, R + 0, and R + 3. The diffusing capacity for carbon monoxide corrected to a standardized alveolar volume (volume-corrected DLCO) was lower in the upright than in the supine posture and decreased in both postures by 20% between baseline and R + 0 and by 5% between baseline and R + 15. Pulmonary blood flow ((Q)over dot(C)) increased from R + 0 to R + 3 by 20 (supine) and 35% (upright). As PF is mostly effort dependent, our data speak against major respiratory muscle deconditioning after 120 days of HDT. The decrease in FEF25-75% suggests a reduction in elastic recoil. Time courses of volume-corrected DLCO and (Q)over dot(C) could be explained by a decrease in central blood volume during and immediately after HDT.