期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 231, 期 1, 页码 97-106出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(01)00874-2
关键词
rifampicin; propylene glycol; castor oil; nonpareil beads; Higuchi model
The rifampicin release studies from ethylcellulose coated nonpareil beads were studied. Propylene glycol and Castor oil were used as plasticizers. The in vitro dissolution studies revealed that the release rate is inversely proportional to percent of coating thickness. The release rate also depends on the type of plasticizer used in the coating polymer. The mechanism of drug release follows Higuchi diffusion model. Water vapour permeation studies indicated that the water vapour transport rate through free films is directly related to the drug release rate. DSC thermograms and IR spectras revealed that there is no interaction between rifampicin and other additives. SEM photographs of coated beads, before dissolution and after dissolution, also indicates that the drug release mechanism follows diffusion model. (C) 2002 Elsevier Science B.V. All rights reserved.
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