期刊
CELLULAR SIGNALLING
卷 51, 期 -, 页码 47-58出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2018.07.012
关键词
lncRNAs; Obesity; White adipogenesis; Brown adipocyte differentiation; Lipid metabolism; Therapeutics
类别
资金
- Key Research and Development Program of Hunan Province of China [2017NK2331, 2016NK2169]
- National Natural Science Foundation of China [31401097]
- Open Research Program of Hunan Provincial Key Laboratory [2017TP1030]
- National High Technology Research and Development Program of China [2013AA102503]
Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of > 200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据