期刊
CELLULAR SIGNALLING
卷 26, 期 9, 页码 1928-1934出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.04.021
关键词
Apoptosis; Mitochondria; Protein import; Bak; Metaxins; Glioma
类别
资金
- INSERM
- Association pour la Recherche contre le Cancer (ARC)
The proteins Bax and Bak are central in the execution phase of apoptosis; however, little is known about the partners involved in the control of this complex process. Here, we show that mitochondrial Bak is incorporated into a VDAC2/Mtx1/Mtx2 multi-protein complex in both resting and dying cells. VDAC2 is a porin that has previously been described as a partner of Bak while Mtx1 and Mtx2 are two proteins of the mitochondrial sorting and assembly machinery (SAM) that have been implicated in TNF-induced apoptosis. We show that, after the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to interact with Mtx1. (C) 2014 Elsevier Inc. All rights reserved.
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