期刊
CELLULAR SIGNALLING
卷 26, 期 7, 页码 1392-1399出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.02.023
关键词
KIBRA; Memory performance; Phosphorylation; Hippo pathway; Cell polarity; Cell migration
类别
资金
- National Institutes of Health [P20 GM103489, R01 GM109066]
- University of Nebraska Medical Center Graduate Studies
- China Scholarship Council
In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond. (C) 2014 Elsevier Inc. All rights reserved.
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