期刊
CELLULAR SIGNALLING
卷 25, 期 12, 页码 2413-2423出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2013.07.025
关键词
Orexins; Orexin receptors; Sleep/wakefulness state; Energy homeostasis; Addiction; Cancers
类别
资金
- High-End Talent Grant of Yunnan Province, China [2012HA008]
The orexin peptides (orexin A. orexin B) and their receptors (orexin receptor type 1, orexin receptor type 2) are involved in multiple physiological processes such as the regulation of sleep/wakefulness state, energy homeostasis and reward seeking. A result of this has been the development of small-molecule orexin receptor antagonists as novel therapies for the treatment of insomnia and drug addiction. Increased levels of signaling via the orexin peptide/receptor system may protect against obesity, while somewhat unexpectedly, orexins acting at orexin receptors induce dramatic apoptosis resulting in the significant reduction of cell growth in various cancer cell lines. Meanwhile, the orexin peptide/receptor system is also involved in cardiovascular modulation, neuroendocrine and reproduction regulation. This review summarizes the latest developments in deciphering the biology of orexin signaling as well as efforts to manipulate orexin signaling pharmacologically. (C) 2013 Elsevier Inc. All rights reserved.
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