期刊
JOURNAL OF NATURAL PRODUCTS
卷 65, 期 3, 页码 249-254出版社
AMER CHEMICAL SOC
DOI: 10.1021/np010427z
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039987, R21AI039987] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI 39987] Funding Source: Medline
- NIGMS NIH HHS [GM 57560] Funding Source: Medline
The structure of the title compound, (+)-7S-hydroxyxestospongin A was solved by single-crystal X-ray diffraction analysis and the absolute stereochemistry obtained by analysis of the derived R and S Mosher's esters. The absolute configuration of xestospongin D was determined for the first time by analysis of anomalous scattering from the X-ray crystal diffraction data set. Xestospongins A, Q and D, araguspongine C, and demethylxestospongin B exhibited modest antifungal activity (MIC 30-100 g/mL) against various fluconazole-resistant Candida spp., but 7S-hydroxyxestospongin A was inactive.
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