Synthesis of α,α-difluoro-β-amino carbonyl-containing sulfonamides and related compounds

Mannich addition reactions between in situ generated alpha,alpha-difluoroenolates and various N-sulfonyl imines readily occur with exceptionally high reaction rates at ambient temperature. The method features remarkable generality and enjoys operationally convenient conditions underscoring its practicality and methodological importance for preparation of sulfonamides bearing beta-amino-alpha,alpha-difluoro ketone moiety. (C) 2015 Elsevier B.V. All rights reserved.