期刊
CELLULAR SIGNALLING
卷 24, 期 8, 页码 1610-1618出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2012.04.001
关键词
cAMP-PKA pathway; Feedback inhibition; Adenylate cyclase; Phosphodiesterase; AKAP; Saccharomyces cerevisiae; Mammalian cells
类别
资金
- Agency for Innovation by Science and Technology (IWT-Flanders)
- KULeuven
- Interuniversity Attraction Poles Network [P6/14]
- Hercules Foundation (Flanders)
The cAMP-protein kinase A (PKA) pathway is a major signalling pathway in the yeast Saccharomyces cerevisiae, but also in many other eukaryotic cell types, including mammalian cells. Since cAMP plays a crucial role as second messenger in the regulation of this pathway, its levels are strictly controlled, both in the basal condition and after induction by agonists. A major factor in the down-regulation of the cAMP level after stimulation is PICA itself. Activation of PKA triggers feedback down-regulation of the increased CAMP level, stimulating its return to the basal concentration. This is accomplished at different levels. The best documented mechanisms are: inhibition of cAMP synthesis by down-regulation of adenylate cyclase and/or its regulatory proteins, stimulation of cAMP breakdown by phosphodiesterases and spatial regulation of cAMP levels in the cell by A-Kinase Anchoring Proteins (AKAPs). In this review we describe these processes in detail for S. cerevisiae, for cells of mammals and selected other organisms, and we hint at other possible targets for feedback regulation of intracellular cAMP levels. (C) 2012 Elsevier Inc. All rights reserved.
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