期刊
CELLULAR SIGNALLING
卷 24, 期 7, 页码 1420-1425出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2012.03.007
关键词
Apoptosis; Apaf-1; Apoptosome; Caspase activation
类别
Apoptosomes are signaling platforms that initiate the dismantling of a cell during apoptosis. In mammals, assembly of the apoptosome is the pivotal point in the mitochondrial pathway of apoptosis, and is prompted by binding of cytochrome c to the apoptotic protease-activating factor 1 (Apaf-1) in the presence of ATP. The resulting wheel-like heptamer of seven molecules Apaf-1 and seven molecules cytochrome c binds and activates the initiator caspase-9, which in turn ignites the downstream caspase cascade. In this review we discuss the molecular determinants for the formation of the mammalian apoptosome and caspase activation and describe the related signaling platforms in flies and nematodes. (c) 2012 Elsevier Inc. All rights reserved.
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