期刊
CELLULAR SIGNALLING
卷 23, 期 9, 页码 1433-1440出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2011.04.007
关键词
Mps one binder; Protein kinase signal transduction; NDR/STK38 and LATS kinases; Protein-protein interactions; Phosphorylation; MEN, SIN and Hippo pathways
类别
资金
- Wellcome Trust [090090/Z/09/Z]
- Wellcome Trust [090090/Z/09/Z] Funding Source: Wellcome Trust
The family of Mps One binder (MOB) co-activator proteins is highly conserved from yeast to man. At least two different MOB proteins have been identified in every eukaryote analysed to date. Initially, yeast genetics revealed essential roles for Mob1p and Mob2p in the regulation of mitotic exit and cell morphogenesis. Studies in flies then showed that dMOB1/MATS is a core component of Hippo signalling. Loss of dMOB1 resulted in increased cell proliferation and decreased cell death, suggesting that MOB1 acts as tumour suppressor protein. Recent work focused primarily on mammalian cells has shown how hMOB1 can regulate NDR/LATS kinases, a function that can to be counteracted by hMOB2. Here we summarise and discuss our current knowledge of this emerging protein family, with emphasis on subcellular localisation, protein protein interactions and biological functions in apoptosis, mitosis, morphogenesis, cell proliferation and centrosome duplication. (C) 2011 Elsevier Inc. All rights reserved.
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