期刊
MECHANISMS OF DEVELOPMENT
卷 110, 期 1-2, 页码 187-191出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00560-3
关键词
PDGF-A; PDGF-B; PDGF-C; PDGFR-alpha; PDGFR-beta; mouse; embryo; development; in situ hybridization; immunohistochemistry; expression; pattern; CUB domain; morphogenesis; somite; mesenchyme; smooth muscle cell; epithelium; chondrocyte; kidney
There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems. Analysis in adult tissues showed that PDGF-C was mainly expressed in kidney, testis, liver, heart and brain. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, and in several other tissues, particularly at sites of developing epidermal openings. PDGF-C may therefore have unique functions during tissue development and maintenance. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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