期刊
CELLULAR SIGNALLING
卷 23, 期 1, 页码 1-5出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2010.07.003
关键词
Polo-like kinase 1; Protein kinase and phosphatase signaling cascade; Ubiquitination; Crosstalk; Mitosis
类别
资金
- National Institutes of Health [DK-56292, CA118948, CA132389]
- NIH, National Center for Research Resources (NCRR)
- Clinical and Translational Science Award program [UL1 RR025008]
- Chinese Natural Science Foundation [90508002, 90913016]
- Chinese Academy of Science [KSCX1-YW-R-65, KSCX2-YW-H-10, KSCX2-YW-R-195]
- Chinese 973 Project [2006CB943603, 2007CB914503, 2010CB912103]
- Anhui Province Key Project Grant [08040102005]
- China Scholarship Council
- NATIONAL CANCER INSTITUTE [P20CA132389, U54CA118948, R01CA164133] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025008] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK056292, R01DK115812] Funding Source: NIH RePORTER
Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. The advancement in optical reporter engineering and the recent development of specific chemical probes enable us to visualize spatiotemporal gradient of kinase activity at nano-scale. One of such tools is FRET-based optic sensor that allows us to delineate the PLK1 activity in space and time. In this review, we address the interrelationships between PLK1 and other protein kinases/phosphatases, as well as the crosstalk between PLK1 phosphorylation and ubiquitination during cell division. In particular, we discuss the molecular mechanisms and steps underlying PLK1 kinase priming, activation and turn-off during cell division. (C) 2010 Published by Elsevier Inc.
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