期刊
CELLULAR SIGNALLING
卷 23, 期 12, 页码 1896-1906出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2011.07.013
关键词
Skeletal muscle; Hypertrophy; Atrophy; Protein metabolism
类别
资金
- NIH [AR057347, F30AG31623]
The maintenance of muscle mass is critical for health and issues associated with the quality of life. Over the last decade, extensive progress has been made with regard to our understanding of the molecules that regulate skeletal muscle mass. Not surprisingly, many of these molecules are intimately involved in the regulation of protein synthesis and protein degradation [e.g. the mammalian target of rapamycin (mTOR), eukaryotic initiation factor 2B (eIF2B), eukaryotic initiation factor 3f (eIF3f) and the forkhead box 0 (FoxO) transcription factors]. It is also becoming apparent that molecules which sense, or control, the energetic status of the cell play a key role in the regulation of muscle mass [e.g. AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1 alpha)]. In this review we will attempt to summarize the current knowledge of how these molecules regulate skeletal muscle mass. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据