期刊
CELLULAR SIGNALLING
卷 21, 期 8, 页码 1245-1254出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2009.02.012
关键词
PTH; PTHrP; PTH1R; Osteoblast; Signaling
类别
资金
- National Institute of Health [DE016865, DK062286]
The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function. (C) 2009 Elsevier Inc. All rights reserved.
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