期刊
CELLULAR SIGNALLING
卷 21, 期 1, 页码 1-6出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2008.06.020
关键词
Arf6; Clathrin-independent; Endocytosis; Macropinocytosis; Phosphoinositides; Signaling; Src; Ras
类别
资金
- Intramural Research Program of the National Heart, Lung and Blood Institute, NIH
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL000517, ZIAHL006060, Z01HL000517] Funding Source: NIH RePORTER
There is increasing interest in endocytosis that occurs independently of clathrin coats and the fates of membrane proteins internalized by this mechanism. The appearance of clathrin-independent endocytic and membrane recycling pathways seems to vary with different cell types and cargo molecules. In this review we focus on studies that have been performed using HeLa and COS cells as model systems for understanding this membrane trafficking system. These endosomal membranes contain signaling molecules including H-Ras, Rac1, Arf6 and Rab proteins, and a lipid environment rich in cholesterol and PIP2 providing a unique platform for cell signaling. Furthermore, activation of some of these signaling molecules (H-Ras, Rac and Arf6) can switch the constitutive form of clathrin-independent endocytosis into a stimulated one, associated with PM ruffling and macropinocytosis. Published by Elsevier Inc.
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