期刊
CELLULAR SIGNALLING
卷 21, 期 2, 页码 196-211出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2008.08.023
关键词
Tetraspanin; Metastasis; Cell adhesion; Signaling; Migration; Invasion; Survival
类别
资金
- American Cancer Society [RSG CSM-109378]
- Department of Defense Prostate Cancer Research Program of the Office of Congressionally Directed Medical Research Programs [W81XWH-08-1-0053]
The recent identification of metastasis suppressor genes, uniquely responsible for negatively controlling cancer metastasis, are providing inroads into the molecular machinery involved in metastasis. While the normal function of a few of these genes is known; the molecular events associated with their loss that promotes tumor metastasis is largely not understood. KAI1/CD82, whose loss is associated with a wide variety of metastatic cancers, belongs to the tetraspanin family. Despite intense scrutiny, many aspects of how CD82 specifically functions as a metastasis suppressor and its role in normal biology remain to be determined. This review will focus on the molecular events associated with CD82 loss, the potential impact on signaling pathways that regulate cellular processes associated with metastasis, and its relationship with other metastasis suppressor genes. (c) 2008 Elsevier Inc. All rights reserved.
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