期刊
CELLULAR SIGNALLING
卷 21, 期 11, 页码 1541-1547出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2009.03.009
关键词
Cell signaling; Cancer; Natural products
类别
资金
- NCI NIH HHS [5R01CA108535, R01 CA083695-07, 5R01CA083695, R01 CA131151-02, R01 CA101870, R01 CA132794, R01 CA131151, R01 CA083695, R01 CA108535, R01 CA131151-02S1, 5R01CA101870, R01 CA132794-01A1, R01 CA101870-05] Funding Source: Medline
Cancer cells are known to have alterations in multiple cellular signaling pathways and because of the complexities in the communication between multiple signaling networks, the treatment and the cure for most human malignancies is still an open question. Perhaps, this is the reason why specific inhibitors that target only one pathway have been typically failed in cancer treatment. However, the in vitro and in vivo studies have demonstrated that some natural products such as isoflavones, indole-3-carbinol (13C), 3,3'-diindolylmethane (DIM), curcumin, (-)-epigallocatechin-3-gallate (EGCG), resveratrol, lycopene, etc, have inhibitory effects on human and animal cancers through targeting multiple cellular signaling pathways and thus these natural agents could be classified as multi-targeted agents. This is also consistent with the epidemiological studies showing that the consumption of fruits, soybean and vegetables is associated with reduced risk of several types of cancers. By regulating multiple important cellular signaling pathways including NF-kappa B, Akt, MAPK, Wnt, Notch, p53, AR, ER, etc, these natural products are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells. Therefore, non-toxic natural agents harvested from the bounties of nature could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies. (C) 2009 Elsevier Inc. All rights reserved.
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