期刊
CELLULAR SIGNALLING
卷 20, 期 6, 页码 999-1009出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2007.11.011
关键词
Wnt; beta-catenin; bone; osteoblasts; mesenchymal stem cells
类别
资金
- NCI NIH HHS [R01 CA100849, CA100849] Funding Source: Medline
- NIDCR NIH HHS [R01 DE016513, DE1016513, R01 DE016513-05, T32DE007057, R01 DE017684, T32 DE007057, R01 DE017684-01A2] Funding Source: Medline
Writ proteins are a family of secreted proteins that regulate many aspects of cellular functions. The discovery that mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, could positively and negatively affect bone mass in humans generated an enormous amount of interest in the possible role of the Wnt signaling pathway in skeletal biology. Over the last decade, considerable progress has been made in determining the role of the canonical Wnt signaling pathway in various aspects of skeletal development. Furthermore, recent evidence indicates the important role of non-canonical Wnt signaling in skeletal development. In this review we discuss the current understanding of the role of Wnt signaling in chondrogenesis, osteoblastogenesis, and osteoclastogenesis. (C) 2007 Elsevier Inc. All rights reserved.
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