期刊
CELLULAR SIGNALLING
卷 20, 期 8, 页码 1415-1422出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2008.02.006
关键词
Dictyostelium; chemotaxis; Ras; Rap; guanine exchange factor; GTP-binding protein
类别
Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.
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