期刊
CELLULAR SIGNALLING
卷 20, 期 1, 页码 1-9出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2007.07.003
关键词
RKIP-1; PEBP; signaling; mouse model; olfaction; reproduction; metastases
类别
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR015578] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P42ES013660] Funding Source: NIH RePORTER
- NCRR NIH HHS [P20 RR015578-076546, 5P20RR015578-07, P20 RR015578, P20 RR015578-076554] Funding Source: Medline
- NIEHS NIH HHS [P42 ES013660, 5P42ES013660-02] Funding Source: Medline
The Raf kinase inhibitory protein 1 (RKIP-1) and its orthologs are conserved throughout evolution and widely expressed in eukaryotic organisms. In its non-phosphorylated form RKIP-1 negatively regulates the Raf/MEK/ERK pathway by interfering with the activity of Raf-1. In its phosphorylated state, RKIP-I dissociates from Raf-1 and inhibits GRK-2, a negative regulator of G-protein coupled receptors (GPCRs). Available data indicate that the phosphorylation of RKIP-1 by PKC can stimulate both the Raf/MEK/ERK and GPCR pathways. RKIP-1 has also been implicated as a negative regulator of the NF-kappa B pathway. Recent studies have shown that phosphorylated RKIP-1 binds to the centrosomal and kinetochore regions of metaphase chromosomes, where it may be involved in regulating the partitioning of chromosomes and the progression through mitosis. The collective evidence indicates that RKIP-l regulates the activity and mediates the crosstalk between several important cellular signaling pathways. A variety of ablative interventions suggest that reduced RKIP-1 function may influence metastasis, angiogenesis, resistance to apoptosis, and genome integrity. Attenuation of RKIP-1 may also affect cardiac and neurological functions, spermatogenesis, sperm decapacitation, and reproductive behavior. In this review, the role of RKIP-1 in cellular signaling, and especially its functions revealed using a mouse knockout model, are discussed. (C) 2007 Elsevier Inc. All rights reserved.
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