期刊
PHARMACEUTICAL RESEARCH
卷 19, 期 3, 页码 239-245出版社
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1014426530935
关键词
aerosol(s); particles; Stoke's Law; density; shape; lung deposition
Key factors that contribute to the aerodynamic properties of aerosol particles are found in Stokes' law. These factors may be monitored or controlled to optimize drug delivery to the lungs. Predictions of the aerodynamic behavior of therapeutic aerosols can be derived in terms of the physical implications of particle slip, shape and density. The manner in which each of these properties have been used or studied by pharmaceutical scientists to improve lung delivery of drugs is readily understood in the context of aerosol physics. Additional improvement upon current aerosol delivery of particulates may be predicted by further theoretical scrutiny.
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