期刊
CLINICA CHIMICA ACTA
卷 317, 期 1-2, 页码 101-107出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0009-8981(01)00771-9
关键词
fluorescence activated cell scanning; FACS; lymphoma; CSF involvement; CSF analysis
Background: Fluorescence activated cell scanning (FACS) is a useful tool for identifying malignant cell clones of lymphoma cells in cerebrospinal fluid (CSF) by immunological phenotype. Methods: We used FACS analysis for demonstrating it to be a quick and reliable technology that is available in most hematological laboratories. In this study, we demonstrate the clinical application of FACS analysis within a series of 15 lymphoma patients with suspected CSF involvement. CSF from three patients with another diagnosis than lymphoma serves as negative control. Results and conclusion: A malignant cell clone cannot only be identified in CSF phenotypically, but also classified according to the immunological surface profile. As this method improves the diagnostic sensitivity and specificity, it should be implemented into routine diagnosis. (C) 2002 Elsevier Science B.V. All rights reserved.
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