期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 30, 期 6, 页码 1526-1537出版社
KARGER
DOI: 10.1159/000343340
关键词
Mesenchymal stem cells; B cells; PGE2; IL-6
资金
- 863 project from the Ministry Science & Technology of China [2011AA020118]
- 973 program of China from the Ministry Science & Technology of China [CB964800, 2011CB964802]
Background: Mesenchymal stem cells (MSC) play important roles in modulating the activities of T lymphocytes, dendritic cells and natural killer cells. These immunoregulatory properties of MSC suggest their therapeutic potential in autoimmune diseases. However, the effects of MSC on B cells are still poorly understood. The present study was designed to investigate the interaction between MSC and B cells both in vitro and in vivo, and to determine the possible mechanism of action. Design and Method: The effect of human umbilical cord mesenchymal stem cells (UC-MSC) on proliferation and differentiation of B-cells were characterized in vitro, and we also tested the immunoregulatory properties of mouse bone marrow MSC (BM-MSC) on T cell dependent and independent antibody production in vivo in mice. Results: Treatment with human UC-MSC resulted in an increase of proliferation, differentiation of B cells into plasma cells and production of antibodies in vitro. Mouse BM-MSC significantly enhanced T cell dependent and independent antibodies production in vivo in mice. PGE2 partially mediated the immunosuppressive activity of human UC-MSC but IL-6 did not regulate this activity. Conclusion: MSC promote proliferation and differentiation of B cells in vitro and in vivo partially through PGE2 but not IL-6. Copyright (c) 2012 S. Karger AG, Basel
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