期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 127, 期 1, 页码 176-182出版社
WILEY
DOI: 10.1046/j.1365-2249.2002.01721.x
关键词
CD3(+)CD56(+) NK T cells; autoimmunity; psoriasis
类别
Psoriasis is a chronic, inflammatory, hyperproliferative skin disease, in which autoimmunity plays a great role. Natural killer T cells (NK T cells), are suggested to be involved in the pathogenesis of different autoimmune diseases. To examine the involvement of CD3(+)CD56(+) NK T cells in the pathogenesis of psoriasis, we investigated the lymphocyte subpopulations obtained from blood samples of psoriatic patients before and after treatment, and of healthy controls, using two-colour flow cytometry. We found no significant differences between total T cells, total B cells, T helper cells, T cytotoxic cells and NK cells in patients with psoriasis before and after treatment and in controls. Increased percentage of memory T cells and decreased percentage of naive T cells was detected in psoriatic patients compared to controls, but these changes were not statistically significant. The CD3(+)CD56(+) cells of psoriatic patients were significantly decreased relative to controls. The percentage of CD3(+)CD56(+) cells increased after different antipsoriatic therapies, but remained significantly lower than those found in controls. CD3(+)CD56(+) cells of healthy controls were capable of rapid activation, while in psoriatic patients activated NK T cells were almost absent. The decrease in the number of CD3(+)CD56(+) cells may represent an intrinsic characteristic feature of patients with psoriasis, which is supported by the fact that after treatment NK T cells do not reach the values found in controls. In conclusion our results suggest that CD3(+)CD56(+) NK T cells could be actively involved in the development of Th1 mediated autoimmune diseases.
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