期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 22, 期 5-6, 页码 373-380出版社
KARGER
DOI: 10.1159/000185448
关键词
Apoptosis; Hemolysis; Red blood cells; Anemia; Sepsis; Malaria
资金
- Deutsche Forschungsgemeinschaft [La 315/4-3, La 315/6-1, La 315/13-1]
- Carl Zeiss-Stiftung
Similar to apoptosis of nucleated cells, suicidal erythrocyte death or eryptosis is characterized by cell shrinkage, membrane blebbing and membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Signaling of eryptosis involves formation of prostaglandin E-2 with subsequent activation of cation channels and Ca2+-entry and/or release of platelet activating factor (PAF) with subsequent activation of sphingomyelinase and formation of ceramide. Ca2+ and ceramide stimulate cell membrane scrambling. Ca2+ further activates Ca2+ sensitive K+-channels leading to cellular KCl loss and cell shrinkage and stimulates the protease calpain resulting in degradation of the cytoskeleton. Injuries triggering eryptosis may similarly compromise survival of nucleated cells. The case is made that analysis of enhanced eryptosis may direct to the pathophysiology of systemic disease. Examples presented include drug side effects, sepsis, haemolytic uremic syndrome, Wilson's disease, phosphate depletion and a rare condition caused by a mutation in GLUT1 turning the carrier into a cation channel. Copyright (c) 2008 S. Karger AG, Basel
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