期刊
AMERICAN JOURNAL OF SURGERY
卷 183, 期 1, 页码 80-86出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9610(01)00843-1
关键词
histologic differentiation; lymphatic invasion; blood vessel invasion; recurrence; intrathyroidal metastasis
类别
Background: Clinicopathological correlation and clinical importance of histologic vascular invasion in differentiated thyroid carcinoma have not been fully examined. Methods: Histologic vascular invasion of 256 differentiated thyroid carcinomas was examined using Victoria-blue hematoxylin-eosin staining. Results: Vascular invasion was found in 120 patients and was independently related to lymph node metastasis (P < 0.0001), extrathyroidal invasion (P = 0.0003) and differentiation (P = 0.0183). Patients with vascular invasion more frequently relapsed than those without (P = 0.0069). The disease-free survival of patients with vascular invasion (15.6 +/- 1.8 years) was shorter than that of patients without vascular invasion (20.5 +/- 0.9 years, P = 0.0001). In multivariate analysis, vascular invasion is an independent prognostic factor for disease-free survival. but not for overall survival. Conclusions: These data suggest that histologic vascular invasion is associated with clinicopathologically aggressive thyroid carcinomas with lymphatic and hematogenous spread and is a prognostic factor for disease-free survival. (C) 2002 Excerpta Medica, Inc. All rights reserved.
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