Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp BCC 3050

A new preussomerin isomer, 3'-O-demethylpreussomerin 1, five known preussomerins E-I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C-11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.