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BLOOD (2012)
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HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src Kinase Hck
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HIV-1 Nef Limits Communication between Linker of Activated T Cells and SLP-76 To Reduce Formation of SLP-76-Signaling Microclusters following TCR Stimulation
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HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
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Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein
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Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases
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HIV-1 Vpu Blocks Recycling and Biosynthetic Transport of the Intrinsic Immunity Factor CD317/Tetherin To Overcome the Virion Release Restriction
Sarah Schmidt et al.
MBIO (2011)
Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes
Laura Andres-Delgado et al.
BLOOD (2010)
The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins
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Uncoordinated 119 Preferentially Induces Th2 Differentiation and Promotes the Development of Asthma
Magdalena M. Gorska et al.
JOURNAL OF IMMUNOLOGY (2010)
HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin
Bettina Stolp et al.
CELL HOST & MICROBE (2009)
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
Robert J. Salmond et al.
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Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain
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JOURNAL OF CELL SCIENCE (2009)
Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation
Magdalena M. Gorska et al.
JOURNAL OF IMMUNOLOGY (2009)
Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4+ T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia
Mir Munir Ahmed Rahim et al.
JOURNAL OF VIROLOGY (2009)
Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the trans-Golgi Network
Mathieu Dube et al.
JOURNAL OF VIROLOGY (2009)
Reversible Phosphorylation as a Molecular Switch to Regulate Plasma Membrane Targeting of Acylated SH4 Domain Proteins
Stella Tournaviti et al.
TRAFFIC (2009)
Role of Nef in primate lentiviral immunopathogenesis
F. Kirchhoff et al.
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Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - From signaling and actin reorganization to migration and phagocytosis
Romain Guiet et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2008)
An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes
Olga Anton et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Induction of HIV Transcription by Nef Involves Lck Activation and Protein Kinase Cθ Raft Recruitment Leading to Activation of ERK1/2 but Not NFκB
Vanessa Witte et al.
JOURNAL OF IMMUNOLOGY (2008)
HIV-1 Nef Induces a Rab11-Dependent Routing of Endocytosed Immune Costimulatory Proteins CD80 and CD86 to the Golgi
Ashutosh Chaudhry et al.
TRAFFIC (2008)
Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting
Dietlinde Wolf et al.
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Human immunodeficiency virus type 1 nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity
Susanne Rauch et al.
JOURNAL OF VIROLOGY (2008)
Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor
Masateru Hiyoshi et al.
BLOOD (2008)
P56Lck tyrosine kinase enhances the assembly of death-inducing signaling complex during fas-mediated apoptosis
Ehssan Sharif-Askari et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
HIV-1 Nef Employs Two Distinct Mechanisms to Modulate Lck Subcellular Localization and TCR Induced Actin Remodeling
Claudia Haller et al.
PLOS ONE (2007)
SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility
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JOURNAL OF CELL SCIENCE (2007)
Human immunodeficiency virus type 1 nef protein modulates the lipid composition of virions and host cell membrane microdomains
Britta Bruegger et al.
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The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements
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HIV-1 nef assembles a src family Kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I
Chien-Hui Hung et al.
CELL HOST & MICROBE (2007)
A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86
Ashutosh Chaudhry et al.
CELL HOST & MICROBE (2007)
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1SF2 Nef
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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-wasp activity
Claudia Haller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
Michael Schindler et al.
CELL (2006)
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
Maria Isabel Thoulouze et al.
IMMUNITY (2006)
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling
A Simmons et al.
IMMUNITY (2005)
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
N Michel et al.
CURRENT BIOLOGY (2005)
Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant
C Stegmayer et al.
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Human immunodeficiency virus type 1 nef activates p21-activated kinase via recruitment into lipid rafts
E Krautkrämer et al.
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The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation - Role in membrane targeting, cell adhesion, and spreading
XQ Liang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structure and regulation of Src family kinases
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Src family kinases, key regulators of signal transduction
SJ Parsons et al.
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Live and let die: Nef functions beyond HIV replication
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HIV Nef increases T cell ERK MAP kinase activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
HIV-1 Nef impairs MHC class II antigen presentation and surface expression
P Stumptner-Cuvelette et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Structure-function relationships in HIV-1 Nef
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Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
A Simmons et al.
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Serine 6 of Lck tyrosine kinase: A critical site for Lck myristoylation, membrane localization, and function in T lymphocytes
K Yasuda et al.
JOURNAL OF IMMUNOLOGY (2000)
Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn
MF Denny et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids
Y Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)