期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 15, 期 3, 页码 230-235出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0895-7061(01)02321-4
关键词
aminoguanidine; sodium excretion; blood pressure; conscious chronically catheterized rat; urinary nitrate plus nitrate; renal hemodynamics
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK045517] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK045517-10, R01 DK 45517] Funding Source: Medline
Background: Previous studies indicate that nitric oxide (NO) is involved in the regulation of blood pressure (BP) and natriuresis in response to high sodium intake. We investigated the role of inducible NO synthase (iNOS) in response to an increased salt intake. Methods: Conscious, chronically catheterized rats were exposed to a high-salt (6%) diet for 14 days while receiving vehicle or aminoguanidine ([AG]; 250 mg/kg/24 h), which selectively inhibits iNOS. A group of rats on normal salt intake + AG were also studied. Results: Aminoguanidine had no impact on BP (120 2 v 116 +/- 1 mm Hg, control v day 14) or 24-h urinary nitrite and nitrate excretion (UNO.,V), in rats on normal salt but prevented lipopolysaccharide-induced hypotension. High salt alone had no impact on BP (120 +/- 1 v 121 +/- 1 mm Hg), whereas UNaV (1.3 +/- 0.2 v 3.5 +/- 0.6 mueq/min, P < .001) and UNOXV increased with high salt intake. The natriuretic response persisted (1.5 +/- 0.2 v 4.3 +/- 0.8 μeq/min, P < .005), but the increase in UNOXV was prevented with chronic AG although BP fell slightly (121 +/- 1 v 115 +/- 1 mm Hg, P < .05). There was no change in plasma volume with high salt, and 24-h UNaV increased appropriately in the presence of AG. The in vitro NOS activity was not increased in kidney homogenates by high salt diet, nor was it affected by chronic AG treatment. Conclusion: We conclude that NO from an iNOS source is not essential for the regulation of sodium excretion and BP in the presence of a high-salt diet in a normal rat. Am J Hypertens 2002 15:2130-235 (C) 2002 American Journal of Hypertension, Ltd.
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